Chetan Patil, Ph.D.
“Optical Spectroscopy for Screening and Diagnosis of Disease: A versatile platform for challenges across the globe”
Optical spectroscopy broadly represents a powerful platform for real-time, non-invasive, analysis of compositional features of disease. Individual spectroscopic approaches are sensitive to a diverse set of molecular and biochemical features, with each approach offering a unique set of advantages, requirements and design opportunities. As clinical science seeks out techniques to more efficiently, safely and accurately evaluate disease, application-specific developments in diffuse reflectance spectroscopy and Raman spectroscopy offer promising opportunities to improve patient care. In this seminar, I will demonstrate the flexibility of optical spectroscopy to address clinical challenges in two very different healthcare settings. In low-resource areas in sub-Saharan Africa, the burden on neonatal jaundice is high due to a lack of quantitative screening protocols. Our group has developed a low-cost mobile phone-based transcutaneous bilirubinometer capable of accurately determining infants bilirubin levels using diffuse reflectance spectroscopy. I will discuss our work in modeling, designing and validating this device in clinical pilot studies. In the United States, the widespread use of cross-sectional imaging has created an entirely different set of clinical challenges, where thousands of unnecessary surgeries are performed each year to remove small, benign renal masses. Our group is seeking to address this problem through the development of a short-wave infrared Raman spectroscopy system specifically designed to improve the specificity of diagnosing malignant kidney tumors. I will discuss our work in developing novel Raman spectroscopy systems to reduce autofluorescence background signals and improve the fidelity of spectroscopic measurements such that accurate classification of malignant from benign kidney tissues is possible. Together, these two projects provide a wide perspective on the versatility optical spectroscopy can provide for addressing clinical challenges in health-care systems across the world.
Chetan Patil is an Assistant Professor of Bioengineering at Temple University in Philadelphia, Pennsylvania. His research interests include development of clinical and translational applications of spectroscopy techniques including Raman and diffuse reflectance, as well as optical imaging techniques that include coherent Raman microscopy and optical coherence tomography. Areas of emphasis include priority issues in global health, neonatology and urologic oncology. He received his Ph.D. in Biomedical Engineering from Vanderbilt University in 2009, where he also served as a Postdoctoral Fellow and Research Assistant Professor in the Department of Biomedical Engineering.