Xavier Intes, Ph.D.
Bioemedical Engineering Co-Director
Rensselaer Polytechnic Institute
“Optical Molecular Imaging Beyond the Microscopy Depth Limit”
Optical imaging techniques are becoming central to the molecular investigation of samples at the macroscopic scale, with a wide range of biomedical applications ranging from pre-clinical assessments of new therapies to image-guided surgical procedures. Especially, fluorescence-based techniques offer the unique advantage of high sensitivity as well as imaging of multiple biomarkers via spectral encoding. Additionally, fluorescence imaging can also be implemented to sense and monitor fluorescence lifetime, providing an additional wealth of information. However, to date, the vast majority of macroscopic investigations are based on topographic imaging. Even though optical tomographic techniques have been developed over the last decade, there is still a lack of efficient approaches for robust 3D imaging, especially for lifetime-based studies and in the mesoscopic regime (beyond the microscopy depth limit).
Dr. Intes will present the efforts of his group towards establishing novel instrumental and theoretical approaches to performing 3D investigation of biotissues at the mesoscopic and macroscopic scale for optical molecular applications. These will include the development of wide-field time-resolved fluorescence molecular tomography based on structured light strategies in preclinical settings as well as mesoscopic fluorescence molecular tomography for high-resolution imaging in shallow tissues. The potential of these imaging platforms will be demonstrated within the context of targeted drug delivery assessment in live animal models and bioprinted tissue constructs.
Xavier Intes is a Professor in the Biomedical Engineering Department and Co-Director of the BioImaging Center at Rensselaer Polytechnic Institute (Troy, U.S.). Dr. Intes received his Ph.D. in physics from Université de Bretagne Occidentale, France. He was a postdoctoral fellow at the University of Pennsylvania under the mentorship of Britton Chance and Arjun Yodh. Dr. Intes was the Chief Scientist of Advanced Research Technologies Inc. (Montreal, Canada) and oversaw the development of two commercial time-resolved tomographic optical imaging platforms: Optix® and SoftScan®. He has been a faculty member of Rensselaer Polytechnic Institute since 2006. He is a recipient of the NSF CAREER award and an AIMBE fellow.
Dr. Intes’ research interests are on the application of optical techniques for biomedical imaging in pre-clinical and clinical settings. His research concentration is on functional imaging of the breast and brain, fusion with other modalities, and fluorescence molecular imaging. The goal of his laboratory is to develop quantitative thick-tissue optical imaging platforms by focusing on three main areas: (a) design of new optical tomographic imaging instrumentation; (b) developing new reconstruction algorithms for quantitative volumetric imaging; and (c) investigating optimal experimental and theoretical parameters for functional, molecular, and dynamical optical imaging.