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Vladimir Torchilin

Affiliated Faculty, Bioengineering
Affiliated Faculty, Chemical Engineering
140 The Fenway, Room 211/214
360 Huntington Avenue
Boston, MA 02115


The efficacy of drug carriers (including liposomes) can be improved by coating them with certain polymers, thus making them long-circulating. Their properties might be still further improved when they are made targeted by attachment of a target-specific antibody. We are conducting an active research on such long-circulating and targeted pharmaceutical carriers for drugs and diagnostics in a variety of in-vitro and in vivo models. II. Many pharmaceutical micelles easily dissociate in vivo. We proposed to use amphiphilic polyethyleneglycol-lipid conjugates for preparing stable polymeric micelles for non-covalent incorporation and delivery of sparingly soluble drugs and diagnostic agents, and are currently investigating very interesting properties of these micelles in vitro and in vivo. III. We have shown that certain non-pathogenic anti-nuclear autoantibodies with nucleosome-restricted specificity are uniquely reactive against the surface of most tumor but not normal cells. Further studies revealed strong anti-tumor potential of these antibodies towards a broad spectrum of tumors. Being used intravenously in normal physiological concentrations, monoclonal antibody 2C5 dramatically inhibits aggressive EL4 T cell lymphoma and B16 melanoma in mice. We study currently the mechanism of mAb 2C5 action which seems to be connected with an antibody-mediated cellular cytotoxicity.


  • PhD, DSc, MS, Moscow State University

Research & Scholarship Interests

Pharmaceutical biotechnology, drug delivery and targeting, nanomedicine, intracellular and organelle-targeted delivery systems, combination cancer therapy
Affiliated With

Department Research Areas

College Research Initiatives

Selected Publications

  • Erdogan S, Torchilin VP., "Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes," Methods Mol Biol.2017;1522:179-192.
  • Yilmaz C, Sarisozen C, Torchilin V, Busnaina A., "Novel Nanoprinting for Oral Delivery of Poorly Soluble Drugs," Methodist Debakey Cardiovasc J. 2016 Sep;12(3):157-162. PMC5098573.
  • Zou W, Sarisozen C, Torchilin VP., "The reversal of multidrug resistance in ovarian carcinoma cells by co-application of tariquidar and paclitaxel in transferrin-targeted polymeric micelles," J Drug Target. 2016 Oct 3:1-10.
  • Moussa M, Goldberg SN, Kumar G, Levchenko T, Torchilin V, Ahmed M., "Effect of thermal dose on heat shock protein expression after radio-frequency ablation with and without adjuvant nanoparticle chemotherapies," Int J Hyperthermia. 2016 Dec;32(8):829-841.

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